1 entry (primary + cross-filed)
Statin therapy carries a documented ~9–12% relative risk increase for new-onset type 2 diabetes, with the effect most pronounced at higher doses (atorvastatin 80 mg shows ~34% relative risk increase). The mechanism appears lipid-independent — likely intracellular cholesterol depletion in pancreatic β-cells and skeletal muscle impairing glucose disposal — rather than a downstream consequence of LDL lowering. The risk is real but typically outweighed by cardiovascular benefit in appropriate candidates.
Last reviewed: 2026-04-17
